Ioannis Koutroubakis

ktjohn@her.forthnet.gr
P.O. BOX:1352
Heraklion, Crete 71110
Greece

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Full Papers in International Medical Journals

1. Koutroubakis I, Crusius JBA, Pena AS. Immunogenetics of cytokines. Relevance for future research in inflammatory bowel disease. Scand J Gastroenterol 1995;30:1139-1146. Medline

2. Koutroubakis I, Manousos ON, Meuwissen SGM, Pena AS. Environmental risk factors in inflammatory bowel disease. Hepatogastroenterol 1996;43:381-393. Medline

3. Bioque G, Crusius JBA, Koutroubakis I, Kostense PJ, Meuwissen SGM, Pena AS. Allelic polymorphism in IL-1â and IL-1 receptor antagonist (IL-1RA) genes in inflammatory bowel disease. Clin Exp Immunol 1995;102:379-383.Medline

4. Bioque G, Bouma G, Crusius JBA, Koutroubakis I, Kostense PC, Meuwissen SGM, Pena AS. Evidence for genetic heterogeneity in IBD. 1.The interleukin-1 receptor antagonist in the predisposition to suffer from ulcerative colitis. Eur J Gastroenterol Hepatol 1996;8:105-110.Medline

5.Bouma G, Xia B, Crusius JBA, Bioque G, Koutroubakis I, Von Blomberg BME, Meuwissen SGM, Pena AS. Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD). Clin Exp Immunol 1996;103:391-396.Medline

6.Koutroubakis I, Xia B, Crusius JBA, Bioque G, Bouma G, Meuwissen SGM, Manousos ON, Pena AS. Tumor necrosis factor-alpha polymorphism in inflammatory bowel disease. Hell J Gastroenterol 1995;8:132-135.

7.Manousos ON, Koutroubakis I, Potamianos S, Roussomoustakaki M, Gourtsoyiannis N, Vlachonikolis IG. A prospective epidemiological study of Crohn's disease in Heraklion, Crete. Incidence over a five year period. Scand J Gastroenterol 1996;31:599-603.Medline

8. Ioannis Koutroubakis, Maria Tzardi, Emanouel Zois, Christos Spiropoulos, Ioannis Mouzas, Orestes Manousos. Granulomatous Appendicitis. A Clinical and Epidemiological study in Crete, Greece. Eur J Gastroenterol Hepatol 1993;5:1061-1065.Infotrieve

9. Manousos ON, Giannadaki E, Mouzas I, Tzardi M, Koutroubakis I, Skordilis P, Vasilakis S, Kouroumalis H, Vlachonikolis IG. Ulcerative colitis is as common in Crete as in Northern Europe. A 5 year prospective study. Eur J Gastroenterol Hepatol 1996;8:893-898.Medline

10. Koutroubakis I, Manousos ON. Smoking and inflammatory bowel disease. Hell J Gastroenterology 1996;9:29-34.Infotrieve

11. IE Koutroubakis. Epidemiology and etiopathogenesis of inflammatory bowel disease. Archives of Hellenic Medicine 1998;15 suppl A:101-104.

12. IE Koutroubakis, H Kritikos, IA Mouzas, SM Spanoudakis, AN Kapsoritakis, E Petinaki, EA. Kouroumalis, ON. Manousos. Association between ulcerative colitis and systemic lupus erythematosus. Report of two cases and review of the literature. Eur J Gastoenterol 1998;10:437-439.Medline

13. EA Kouroumalis, IE Koutroubakis, ON Manousos. Somatostatin for acute severe bleeding in portal hypertensive gastropathy. Eur J Gastoenterol 1998;10:509-512.Medline

14. IE Koutroubakis, E Petinaki, E Anagnostopoulou, H Kritikos, IA Mouzas, EA Kouroumalis, ON Manousos. Anticardiolipin and anti-â2-glycoprotein I antibodies in patients with inflammatory bowel disease. Dig Dis Sci 1998;43:2507-2512.Medline

15. IA Mouzas, E Papavassiliou, I Koutroubakis. Chemoprevention of colorectal cancer in inflammatory bowel disease? A potential role for folate. Italian J Gastroenterol 1998;30:421-5.Medline

16. IE Koutroubakis, IG Vlachonikolis, A Kapsoritakis, S Spanoudakis, M Roussomoustakaki, IA Mouzas, EA Kouroumalis, ON Manousos. Appendectomy, tonsillectomy and risk of inflammatory bowel disease. A case controlled study in Crete. Dis Colon Rectum 1999;42:225-230.Medline

17. M Koulentaki, IE Koutroubakis, E Petinaki, M Tzardi, H Oekonomaki, I Mouzas, EA Kouroumalis. Ulcerative colitis associated with primary biliary cirrhosis. Dig Dis Sci 1999;44:1953-1956.Medline

18. IE Koutroubakis, IG Vlachonikolis. Appendectomy and the development of ulcerative colitis a causal relationship. Results of a meta-analysis of published case-control studies. Am J Gastroenterol 2000;95:171-176.Medline

19. I.E. Koutroubakis, A. Sfiridaki, I.A. Mouzas, A. Maladaki A. Kapsoritakis, M. Roussomoustakaki, E.A. Kouroumalis, O.N. Manousos. Resistance to activated protein C and low levels of free Protein S in Greek patients with inflammatory bowel disease Am J Gastroenterol 2000;95:190-194.Medline

20. S Potamianos, IE Koutroubakis, C Chatzicostas, K Rolles, AK Burroughs, EA Kouroumalis. Idiopathic fibrosing pancreatitis and Crohn's disease. An interesting association. Eur J Gastroenterol Hepatol 2000;12:1021-1024.Medline

21. AN Kapsoritakis, A Sfiridaki, MI Koukourakis, SP Potamianos, IE Koutroubakis, G Eliopoulos, ON Manousos, EA Kouroumalis. Thrombopoietin serum levels in patients with inflammatory bowel disease. Am J Gastroenterol 2000;95:3478-81.Medline

22. M Roussomoustakaki, S Potamianos,IG Vlachonikolis, E Anagnostopoulou, I Koutroubakis, E Matrella, ON Manousos, E Kouroumalis. Low mortality and morbidity of upper gastrointestinal bleeding in Crete. The role of individual non steroidal anti-inflammatory drugs. Annals of Gastroenterology 2000;13:225-232

23. IE Koutroubakis, E Dilaveraki, IG Vlachonikolis, E Vardas, G Vrentzos, E Ganotakis, IA Mouzas, A Gravanis, D Emmanouel, EA Kouroumalis. Hyperhomocysteinemia in Greek patients with Inflammatory Bowel Disease. Dig Dis Sci 2000;45:2347-2351.Medline

24. IE Koutroubakis, E Petinaki, IA Mouzas, E Anagnostopoulou, IG Vlachonikolis, AN Maniatis, E Castanas, EA Kouroumalis. Anti Saccharomyces cerevesiae mannan antibodies and antineutrophil cytoplasmic autoantibodies in Greek patients with Inflammatory Bowel Disease. Am J Gastroenterol 2001;96:449-454.Medline

25. IE Koutroubakis. Role of thrombotic risk factors in inflammatory bowel disease. Dig Dis 2000;18:161-167.Medline

26. AN Kapsoritakis, MI Koukourakis, A Sfiridaki, SP Potamianos, MG Kosmadaki, IE Koutroubakis, EA Kouroumalis. Mean platelet volume. A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776-781.Medline

27. MG Alexandrakis, D Kyriakou, IE Koutroubakis, R Alexandraki, IG Vlachonikolis, GD Eliopoulos. Assaying of tumor necrosis factor alpha, complement factors and alpha-1-antitrypsin in the diagnosis of malignant serous effusions. Am J Clin Oncol 2001;24:562-565.Medline

28. IE Koutroubakis. Unraveling the mechanisms of thrombosis in Inflammatory Bowel Disease (Editorial) Am J Gastroenterol 2001;96:1325-1327.Medline Full Paper

29. IE Koutroubakis, N. Malliaraki, E. Vardas, E Ganotakis, AN Margioris, ON Manousos, EA Kouroumalis. Increased levels of Lipoprotein (a) in Crohn’s disease; a relation to thrombosis? Eur J Gastroenterol Hepatol 2001;13:1415-1419.Medline. .Editorial.

30. IE Koutroubakis, A Sfyridaki, A Theodoropoulou, EA Kouroumalis. Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients. Gastroenterology 2001;121:561-565.Medline. .Editorial.

31. IG Vlachonikolis, IE Koutroubakis, ON Manousos. Epidemiology of inflammatory bowel disease in Heraklion Crete. Scand J Gastroenterol 2001;36:1008.Medline.

32. Dimoulios P, Koutroubakis IE, Sfiridaki A, Theodoropoulou A, Kouroumalis EA. Acquired and hereditary thrombotic risk factors in patients with acute mesenteric vein thrombosis. Am J Gastroenterol 2002:97:768-769. Medline.

33. Koutroubakis IE, Petinaki E, Vardas E, Dimoulios P, Roussomoustakaki M, Maniatis AN, Kouroumalis EA. Circulating Soluble Vascular Adhesion Protein 1 in patients with Inflammatory Bowel Disease.Eur J Gastroenterol Hepatol 2002;14:405-408.Medline.

34. Chatzicostas C, Koutroubakis IE, Tzardi M, Roussomoustakaki M, Prassopoulos P, Kouroumalis EA. Colonic tuberculosis mimicking Crohn's disease: case report. BMC Gastroenterol. 2002;2:10.Medline.

35.IE Koutroubakis, IG Vlachonikolis, EA Kouroumalis.The role of appendicitis and appendectomy in the pathogenesis of ulcerative colitis: A critical review Inflam Bowel Dis 2002;8:277-286.Medline.

36.AN Kapsoritakis, IE Koutroubakis, EA Kouroumalis, SI Koukouraki, N Karkavitsas. 99mTc-Leucoscan in the evaluation of inflammatory bowel disease. Eur J Nucl Med 2002;29:1098 .Medline.

37.IE Koutroubakis, E Petinaki, P Dimoulios, E Vardas, M Roussomoustakaki, A N Maniatis, EA Kouroumalis. Increased serum levels of YKL-40 in patients with Inflammatory Bowel Disease. Int J Colorect Dis 2003;18:254-9.Medline.

38.Kyriakou DS, Alexandrakis MG, Passam FH, Foundouli K, Matalliotakis E, Koutroubakis IE, Kourelis TV, Chalkiadakis G, Manoussos ON. Acquired inhibitors to coagulation factors in patients with gastrointestinal diseases. Eur J Gastroenterol Hepatol 2002;14:1383-1387.Medline.

39.Roussomoustakaki M, Koutroubakis I, Vardas EM, Dimoulios P, Kouroumalis EA, Baritaki S, Koutsoudakis G, Krambovitis E. NOD2 Insertion Mutation in a Cretan Crohn’s Disease Population. Gastroenterology 2003;124:272-273. Medline.

40.Koutroubakis IE, Theodoropoulou A,Kouroumalis EA. Transient ischaemic colitis following an aeroplane flight. Gut 2003;52:1072-3.Medline.

41.Koutroubakis IE, Petinaki E, Dimoulios P, Vardas E, Roussomoustakaki M, Maniatis AN, Kouroumalis EA. Serum levels of Laminin and Collagen IV in patients with Inflammatory Bowel Disease. J Clin Pathol 2003;56:817-20Medline.

42.Koutroubakis IE, Koukouraki SI, Dimoulios PD, Velidaki AA, Karkavitsas NS, Kouroumalis EA. Active Inflammatory Bowel Disease: Evaluation with 99mTc (V) DMSA Scintigraphy. Radiology 2003;229:70-4Medline.

43.Koutroubakis IE, Theodoropoulou A, Sfiridaki A, Kouroumalis EA. Low plasma protein Z levels in patients with ischemic colitis. Dig Dis Sci 2003;48:1673-6. Medline.

44.Dimoulios P, Koutroubakis IE, Tzardi M, Antoniou P, Matalliotakis IM, Kouroumalis EA. A case of sigmoid endometriosis difficult to differentiate from colon cancer. BMC Gastroenterology 2003 3:18.Medline.

45.Theodoropoulou A, Koutroubakis IE, Kouroumalis EA.Treatment of oesophageal Crohn’s disease with infliximab. Eur J Gastroenterol Hepatol 2004;16:431-432.Medline.

46. Samonakis D, Koutroubakis IE, Sfiridaki A, Maliaraki N, Romanos J, Kouroumalis EA. Hypercoagulable states in patients with hepatocellular carcinoma. Dig Dis Sci 2004;49:854–858.Medline.

47.Koutroubakis IE, Malliaraki N, Dimoulios P, Karmiris K, Castanas E, Kouroumalis EA. Decreased total and corrected antioxidant capacity in patients with inflammatory bowel disease. Dig Dis Sci 2004;49:1433-7.Medline.

48.Koutroubakis IE, Theodoropoulou A, Xydakis K, Sfiridaki A, Notas G, Kouroumalis EA. Association between enhanced soluble CD40L and prothrombotic state in inflammatory bowel disease. Eur J Gastroenterol Hepatol 2004;16:1147-52.Medline.

49.Koutroubakis IE, Xidakis C, Karmiris K, Sfiridaki A, Kandidaki E, Kouroumalis EA. Serum angiogenin in inflammatory bowel disease. Dig Dis Sci 2004;49:1758-62.Medline.

50. Koutroubakis IE, Antoniou P, Tzardi M, Kouroumalis EA.The spectrum of segmental colitis associated with diverticulosis. Int J Colorectal Dis 2005;20:28-32.Medline.

51.Karmiris K, Koutroubakis IE, Kouroumalis EA. The emerging role of adipocytokines as inflammatory mediators in inflammatory bowel disease. Inflam Bowel Dis 2005;11;847–855.Medline.

52.Koutroubakis IE. Vascular complications in patients with inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol 2005;2:266-272.Medline.

53.Koutroubakis IE, Drygiannakis D, Karmiris K, Drygiannakis I, Makreas S, Kouroumalis EA. Pancreatic Autoantibodies in Greek Patients with Inflammatory Bowel Disease. Dig Dis Sci 2005;50:2330-2334.Medline.

54.Wolters F, Russel MG, Sijbrandij J, Ambergen T, Odes S, Riis L, Langholz E, Politi P, Qasim A, Koutroubakis I, Tsianos E, Vermeire S, Freitas J, van Zeijl G, Hoie O, Bernklev T, Beltrami M, Rodriguez D, Stockbrügger RW, Moum B. Phenotype at diagnosis predicts recurrence rates in Crohn’s disease. Gut 2006;55:1124-30.Medline.

55.Koutroubakis IE, Xidakis C, Karmiris K, Sfiridaki A, Kandidaki E, Kouroumalis EA. A Potential Role of Soluble Angiopoietin-2 and Tie-2 in patients with Inflammatory Bowel Disease. Eur J Clin Invest 2006;36:127-132.Medline.

56.Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA.Circulating levels of Leptin, Adiponectin,Resistin and Ghrelin in Inflammatory Bowel Disease. Inflam Bowel Dis2006;12:100-5 .Medline.

57.Koutroubakis IE, Tsiolakidou G, Kouroumalis EA. Inherited thrombophilia and thrombosis in inflammatory bowel disease. Am J Gastroenterol 2006;101:403.Medline.

58.Koutroubakis IE, Karmiris K, Makreas S, Xidakis C, Niniraki M, Kouroumalis EA. Effectivenes of darbepoetin alfa in combination with intravenous iron sucrose in patients with inflammatory bowel disease and refractory anemia. A pilot study. Eur J Gastroenterol Hepatol 2006;18:421-5.Medline.

59.Koutroubakis IE, Karmiris K, Kouroumalis EA. Treatment of anaemia in inflammatory bowel disease. Aliment Pharmacol Ther 2006;23:1273-4.Medline.

60.Koutroubakis IE, Tsiolakidou G, Karmiris K, Kouroumalis EA. Role of angiogenesis in inflammatory bowel disease. Inflam Bowel Dis 2006;12:515-23.Medline.

61.Gourtsoyiannis NC, Grammatikakis J, Papamastorakis G, Koutroumbakis J, Prassopoulos P, Rousomoustakaki M, Papanikolaou N. Imaging of small intestinal Crohn's disease: comparison between MR enteroclysis and conventional enteroclysis. Eur Radiol 2006;16:1915-25.Medline.

62.Koutroubakis IE, Drygiannakis D, Karmiris K, Drygiannakis I, Bourikas L, Kouroumalis EA. Antibodies against cyclic citrullinated peptide (CCP) in inflammatory bowel disease patients with or without arthritic manifestations. Inflam Bowel Dis 2007;13:504-505.Medline.

63.Koutroubakis IE, Sfiridaki A, Tsiolakidou G, Theodoropoulou A, Livadiotaki A, Paspatis G, Kouroumalis EA. Genetic risk factors in patients with inflammatory bowel disease and vascular complications. A case control study. Inflam Bowel Dis 2007;13:410-415.Medline.

64.Koutroubakis IE. The patient with persistent perianal fistulae. Best Clin Pract Res Gastroenterol 2007;21:503-18.Medline.

65.Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA. The effect of Infliximab on circulating levels of Leptin, Adiponectin and Resistin in patients with Inflammatory Bowel Disease. Eur J Gastroenterol Hepatol 2007;19:789-794.Medline.

66.Tsiolakidou G, Koutroubakis IE. Stimulating erythropoiesis in inflammatory bowel disease associated anemia. (Editorial) World J Gastroenterol 2007;13:4798-4806.Medline.

67.Karmiris K, Koutroubakis IE.Resistin: another rising biomarker in inflammatory bowel disease? (Editorial) Eur J Gastroenterol Hepatol 2007;19:1035-1037.Medline.

68.Gasche C, Berstad A, Befrits R, Beglinger C, Dignass A, Erichsen K, Gomollon F, Hjortswang H, Koutroubakis I, Kulnigg S, Oldenburg B, Rampton D, Schroeder O, Stein J, Travis S, Van Assche G.. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflam Bowel Dis 2007;13:1545-1553.Medline.

69.Bourikas LA, M Tzardi M, Hatzidakis A, Koutroubakis IE. Small bowel perforation due to Non-Hodgkin-Lymphoma in a patient with Ulcerative Colitis and Systemic Lupus Erythematosus. Dig Liver Dis 2008;40:144.Medline.

70.Stathaki M, Koutroubakis IE, Koukouraki S, Karmiris K, Moschandreas J , Kouroumalis EA, Karkavitsas N.. Active inflammatory bowel disease; Head to head comparison between 99mTc-HMPAO-WBC and 99mTc (V) DMSA scintigraphy. Nuclear Medicine Communications 2008;29:27-32.Medline.

71.Bourikas LA, Kourbeti IS, Koutsopoulos AV, Koutroubakis IE. Disseminated Tuberculosis in a Crohn’s Disease patient on anti-TNF-α therapy despite chemoprophylaxis. Gut 2008;57:425.Medline.

72.Karmiris K, Koutroubakis IE, Kouroumalis EA.Leptin, adiponectin, resistin and ghrelin; implications for inflammatory bowel disease. Molecular Nutrition and Food Research (in press).Medline.

73.Koutroubakis IE, Sfiridaki A, Tsiolakidou G, Coucoutsi C, Theodoropoulou A, Kouroumalis EA. Plasma thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor -1 levels in inflammatory bowel disease. Eur J Gastroenterol Hepatol 2008;20:912-916 .Medline.

74.Tsiolakidou G, Koutroubakis IE, Tzardi M, Kouroumalis EA. Increased expression of VEGF and CD146 in patients with inflammatory bowel disease. Dig Liv Dis 2008;40:673-9.Medline.

75.Karimi O, Crusius JBA, Coucoutsi C, Heijmans R, Sambuelli AM, Peña AS, Koutroubakis IE. The JAK2 V617F Mutation is not involved in thromboembolism in IBD. Inflam Bowel Dis 2008 (in press).Medline.

76.Theodoropoulou A, Sfiridaki A, Oustamanolakis P, Vardas E, Livadiotaki A, Mpoumpaki A, Paspatis G, Koutroubakis IE. Genetic risk factors in young patients with ischemic colitis. Clin Gastroenterol Hepatol 2008;6:907-11.Medline.

77.Tsiolakidou G, Koutroubakis IE.Thrombosis and inflammatory bowel disease-the role of genetic risk factors. World J Gastroenterol. 2008;14:4440-4.Medline.

78.Koutroubakis IE.Venous Thromboembolism in hospitalized inflammatory bowel disease patients:The magnitude of the problem is staggering. Am J Gastroenterol(Editorial)2008;103:2281-2283.Medline.

79.Stathaki M, Koutroubakis IE, Koukouraki S, Kouroumalis EA, Karkavitsas N. Is there a role of 99mTc (V) DMSA scintigraphy in ischemic colitis? World J Gastroenterol 2008;14:5432-5435.Medline.

80.Koutroubakis IE. The spectrum of non-inflammatory bowel disease and non-infectious colitis. World J Gastroenterol 2008;14:7277-7259.Medline.

81.Theodoropoulou A, Koutroubakis IE. Ischemic colitis: Clinical practice in diagnosis and treatment. World J Gastroenterol 2008;14:7302-7308.Medline.

82.Koutroubakis IE, Oustamanolakis P, Malliaraki N, Karmiris K, Chalkiadakis I, Ganotakis E, Karkavitsas N, Kouroumalis EA. Effects of TNF-α inhibition with Infliximab on lipid levels and insulin resistance in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol 2009;21:283-288.Medline.

Chapters in Books

1. Pena AS, Crusius JBA, Koutroubakis I, Bioque G, Bouma G, Pladdet IE, Oudejans, Doekhie FS, Meuwissen SGM. Preliminary results on cytokine and mucin gene polymorphism. In Inflammatory bowel disease. Tytgat, Bartlesman, van Deventer ed.Kluwer academic publishers 1995:232-238.Internet Site

2. A.S. Pena, J.B.A. Crusius, G. Bioque, I. Koutroubakis, G. Bouma, L.A. Dieleman, J.J. Kolkman, S.G.M. Meuwissen. Pathogenetic mechanisms of IBD. Immunogenetics and epidemiology. Congresso Nazionale delle malattie digestive (Italian congress of Gastroenterology) Book of the congress 1994;4-11.

3. Koutroubakis I, Pena AS. Genetics of inflammatory bowel disease. In: Inflammatory bowel disease. Edited by Allan RN, Rhodes JM, Hanauer SB, Keighley MRB, Alexander-Williams J, Fazio VW. Churchill Livingstone 3th ed, 1997:13-26.Internet Site

4. IE Koutroubakis. Genetics of Inflammatory Bowel Disease. 1st Mediterranean Summer School. Topic Inflammatory Bowel Disease. Moderator ON Manousos. 25-27 September 1998, Samos Greece. Book of the congress 1998;97-100.

5. IE Koutroubakis. Diagnosis of Colorectal cancer. 1st Mediterranean Summer School. Topic Colon cancer. Moderator ON Manousos. 25-27 September 1998, Samos Greece. Book of the congress 1998; 140-143.

6. Notas G, Koutroubakis IE, Kouroumalis EA. Oxidants and Antioxidants in Liver disease. In “Antioxidants: New Research” Panglossi HV ed Nova Publishers 2006:1-48

· Abstracts of 85 papers have been published in various journals (Gastroenterology, Gut, Digestion, The Journal of Rheumatology, Neth J Med) on various aspects of gastroenterology.

· 25 full papers and 124 Abstracts have been published in the Greek Medical Literature.